Muneshwar Rajput1, Pushpendra D. Pratap1, Saliha Rizvi1, Syed Tasleem Raza1*, Vineeta Khare 2
1Central Research Laboratory, Molecular Diagnostic Unit, Department of Biochemistry, ERA’S
Lucknow Medical College, ERA University, Lucknow-226003, Uttar Pradesh, India
2Department of Microbiology, ERA’S Lucknow Medical College, ERA University, Lucknow-
226003, Uttar Pradesh, India
*Correspondence Email Address: [email protected]
ABSTRACT
An important factor in dysfunction of renal, renal fibrosis, as well as renal disease, diabetic nephropathy (DN) is one of the most prevalent thoughtful microvascular consequences in patients with diabetes. Unfortunately, DN’s pathophysiology is complicated and has not yet been effusively understood. As a result, substantial research is being done to find effective therapeutics, which is crucial. Early studies on DN concentrated on structural modifications and metabolic abnormalities, but more current research have revealed the impact of miRNAs in gene regulation, which may be a novel diagnostic marker for DN and a response to therapy. In this review, we discuss current developments in the clinical utility and molecular processes of DN miRNA, offering fresh perspectives on DN treatment and management.
Keywords: Diabetic Nephropathy, Nephropathy Pathophysiology, Metabolic Abnormalities
Citation: Muneshwar Rajput, Pushpendra D. Pratap, Syed Tasleem Raza. Role of Regulatory Micrornas Associated with the Pathogenicity of Diabetic Nephropathy. Canadian Journal of Clinical Nutrition. 2023; 11 (2): 75-96.
DOI: https://dx.doi.org/10.14206/canad.j.clin.nutr.2023.02.07
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