Anti-inflammatory Role of Vitamin D among Type 2 Diabetic Patients with Infection

Doha M. Abou-Zahra1*, Nawal A. El-Sayed2, Skeena A. Ismail3, Rana Emara2

1Nutrition Department, Faculty of Applied Health Sciences Technology, Pharos University, Alexandria, Egypt. 2Nutrition Department, High Institute of Public Health, Alexandria University, Egypt. 3Internal Medicine, Faculty of Medicine, Alexandria University, Egypt

*Corresponding author:  Dr. Doha Magdy Abou-Zahra, Assistant lecturer of Nutrition of Pharos University, Alexandria, E-mail: [email protected]


Background: Type 2 diabetes is a metabolic disorder that is associated with several complications. Recently it was suggested that vitamin D deficiency may play a vital role in the development and progression of diabetes and may impact the outcome of the disease and its associated co-morbidities as sepsis and cardiovascular disease. This study aimed to evaluate the anti-inflammatory role of vitamin D in patients with type 2 diabetes mellitus having infection and determine the effects of vitamin D supplementation on serum 25-(OH) vit. D, the metabolic profile, and inflammatory markers. Subjects and Methods: A sample of 170 patients having type 2 diabetes with infection were involved in the study. They were divided into control group receiving appropriate antibiotic therapy and intervention group receiving vitamin D supplementation (10,000 IU daily for three months) beside the antibiotic therapy. Serum 25-(OH) vitamin D, glycemic profile, random blood glucose level (RBG) and glycated hemoglobin (HbA1c) and inflammatory markers, (C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and tumor necrosis factor-alpha (TNF-α) were done at the start of the study and after three months. The outcome in the two groups was assessed at the end of the study. Results: Vitamin D is negatively correlated with RBG, HbA1c, body mass index, CRP, ESR, TNF-α. The intervention group had a better outcome at the end of the three months than the control group in terms of higher serum 25-(OH) vitamin D, good glycemic control, decreased serum levels of ESR, CRP, and TNF-α. Conclusion: Vitamin D has a strong anti-inflammatory effect and positively impacts the glycemic profile and clinical condition of patients with type 2 diabetes having infection.

Keywords: Anti-Inflammatory Effect, Glycemic Profile, Type 2 Diabetes, Vitamin D

Citation: Doha M. Abou-Zahra, Nawal A. El-Sayed, Skeena A. Ismail, Rana Emara. Anti-inflammatory Role of Vitamin D among Type 2 Diabetic Patients with Infection. Canadian Journal of Clinical Nutrition. 2021; 9 (1): 34-60.