Structure, Function and Role of S Protein of SARS CoV-2 Virus in Drug Development

Kaynat Fatima, Sanchita Srivastava, Saliha Rizvi, Syed Tasleem Raza*

Department of Biochemistry, Era’s Lucknow Medical College and Hospital, Lucknow,
India

*Email Address of Correspondence: tasleem24@gmail.com

ABSTRACT

Coronavirus illness 2019 is a new viral disease that is now sweeping the globe. It is caused by a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS- CoV-2). The spike (S) protein of SARS-CoV-2, which plays a key role in the receptor recognition and cell membrane fusion process, is made up of two subunits, S1 and S2. The receptor-binding domain of the S1 subunit identifies and binds to the host receptor angiotensin-converting enzyme2, whereas the two-heptad repeat domain of the S2 subunit promotes viral cell membrane fusion by producing a six-helical bundle. In this review, we highlight recent research advances in the structure, function and role of S protein in antivirus drug development.

Keywords: Angiotensin Converting Enzyme 2, Fusion Protein, SARS-CoV-2 Virus, Spike
Protein

Citation: Kaynat Fatima, Sanchita Srivastava, Saliha Rizvi, Syed Tasleem Raza. Structure,
function and role of S protein of SARS CoV-2 virus in drug development. Canadian Journal of
Clinical Nutrition. 2023; 11 (1): 121-130.

DOI: https://dx.doi.org/10.14206/canad.j.clin.nutr.2023.01.10

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