Carrageenan Extracted from Hypnea bryodies Seaweed Attenuates Streptozotocin-Induced Hyperglycemia, Oxidative Stress and Pancreatic Histopathological Changes in Diabetic Rats

Zainab M. Al-Nahdi1, Ahmed Al-Alawi1*, Nasneen Althaf1, Mohamed A. Al-Kindi2, Halima K. Al-Issaei2, Sultan N.M. Al-Maskari3, Bader R.S. Al-Ruqaishi3, Ahmed Al-Salami4

1Department of Food Science and Nutrition, College of Agricultural and Marine Sciences, Sultan Qaboos University; 2Pathology Department, College of Medicine and Health Sciences, Sultan Qaboos University; 3Small Animal House, College of Medicine and Health Sciences, Sultan Qaboos University; 4 Ministry of Health, Sultanate of Oman

*Corresponding Author: Dr. Ahmed Al-Alawi. E-mail address: [email protected]


Background: Several studies have reported the efficacy of carrageenan extracted from different seaweeds in the prevention of diabetes, yet there is scarce knowledge about the biochemical aspects of carrageenan extracts in relation to diabetes. Objective: This study aimed to evaluate the hypoglycemic and antioxidant potential properties of carrageenan extracted from Hypnea bryodies seaweed in diabetic rats. Materials and Methods: Streptozotocin (STZ) drug was used as a diabetogenic agent in a single intraperitoneal injection dose of 60 mg/kg body weight of male Sprague-Dawley rats. Diabetic and non-diabetic rats were fed chow diet plus oral feeding of either carrageenan extracted from Hypnea bryodies or standard carrageenan. After 12 weeks, following STZ injection, all animals were overnight fasted and sacrificed; pancreas tissues were homogenized for antioxidants measurements and histopathological examination of pancreatic islet. Results: Extracted carrageenan and standard carrageenan were comparable in attenuating the STZ-induced hyperglycemia, oxidative stress and pancreatic histopathological changes in diabetic rats. Conclusion: The results of this in-vivo study demonstrate that carrageenan extracted from Hypnea bryodies seaweed has a protective effect against STZ-induced hyperglycemia and pancreatic cells injury via reducing oxidative stress.

Keywords: Oxidative stress, Diabetes, Seaweed, Carrageenan

Citation: Al-Nahdi ZM, Al-Alawi A, Althaf N, Al-Kindi MA, Al-Issaei HK, Al-Maskari SNM, Al-Ruqaishi BRS, Al-Salami A. Carrageenan extracted from Hypnea bryodies seaweed attenuates streptozotocin-induced hyperglycemia, oxidative stress and pancreatic histopathological changes in diabetic rats. Canad J Clin Nutr 2016; 4 (2): 4-15.