Marwa Hamed Said Al-Muqbali, Ahmed Al-Alawi*, Mostafa I. Waly, Mohammad Shafiur Rahman
Food Science and Nutrition Department, College of Agricultural and Marine Sciences, Sultan Qaboos University, Muscat, Oman
*Corresponding Author Email Address: [email protected]
ABSTRACT
Background: Sultanate of Oman is one of rich country in natural resources like seaweeds. Seaweeds can be used as food or feedstock for industrial processes. Fucoidans are sulfated polysaccharides are of high biological value extracted from brown seaweeds. Stomach cancer is the third most common cause of cancer death worldwide, yet there no current study investigated the role of seaweed in gastric cancer prevention. Objective: This study aimed to study the anticancer properties of fucoidans, sulfated polysaccharides, extracted from seaweeds Methods: Sundried powder of Sargassum ilicifolum was used to extract fucoidans polysaccharides. Four rats groups of control group, Nitrosamine (NA) injected group, fucoiadans extract supplemented group and NA –injected supplemented with fucoidans extract group, were used to investigate the antioxidant and anticancer properties of fucoidans against NA-induced oxidative stress and gastric cancer pathogenesis. Results: The protective effect against oxidative stress in rat stomach cells injected with (NA) and treated with fucoidans was evidenced by improvement in the structure of mitochondria organelle with decrease in its dense matrix. Conclusion: The results of this study suggested that fucoidans extracted from Sargassum ilicifolum has the potential to inhibit the chemically-induced oxidative stress in rat gastric cells, which might be attributed to its high content of sulfate.
Keywords: Anticancer Properties, Brown Seaweed, Fucoidans, Gastric Cancer, Oman
Citation: Marwa Hamed Said Al-Muqbali, Ahmed Al-Alawi, Mostafa I. Waly, Mohammad Shafiur Rahman. Anticancer Properties of Fucoidans Extracted from Brown Seaweed (Sargassum ilicifolium) In a Rat Model of Gastric Cancer. Canadian Journal of Clinical Nutrition 2019; 7 (2): 43-61.
DOI: http://dx.doi.org/10.14206/canad.j.clin.nutr.2019.02.04