Impact of Vitamin K Intake on the Effectiveness of Oral Anticoagulant Treatment

Dunia Ali Hussien Al-Hadithi*
Department of Pharmacology and Clinical Pharmacy, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman
*Corresponding Author:Dunia Al-Hadithi. E-mail:duniaalhadithi@gmail.com

ABSTRACT
Using systematic review of observational and interventional studies, it was concluded that patients treated with vitamin K antagonists are in need to adjust their dietary intake of vitamin K during their anticoagulant therapy.Vitamin K is an essential cofactor for the post-translational carboxylation of various proteins involved in blood coagulation. For many years, patients treated with vitamin K antagonistshave been advised to reduce dietary vitamin K content to avoid food and drug interaction which might influence anticoagulation stability. Many patients on warfarin are vitamin K depleted as a result of routine instructions to restrict vitamin K intake as an attempt to achieve optimal therapeutic response.The objective of thiseditorial is to address the influence of thevitamin K rich foods on vitamin K antagonists.

Keywords: Vitamin K, Oral Anticoagulant, Diet, Treatment

Citation: Al-Hadithi DAH. Impact of Vitamin K Intake on the Effectiveness of Oral Anticoagulant Treatment. Canad J ClinNutr 2017; 5 (2): 1-5.

DOI:http://dx.doi.org/10.14206/canad.j.clin.nutr.2017.02.1

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