Molecular Biology of Human Papillomavirus, Cervical Carcinoma and its Management

Pushpendra Pratap, Tasleem Raza*, Ghazala Zaidi, Mark Rector Charles, Shipra Kunwar                                 

Department of Biochemistry, Era’s Lucknow Medical College and Hospital, Lucknow, India- 226003

*Correspondence Email Address: Professor Syed Tasleem Raza, Department of Biochemistry, Era’s Lucknow Medical College and Hospital, Lucknow, India-226003. E-mail: tasleem24@gmail.com

ABSTRACT

Cancer arises from several molecular events which alter the properties of normal cells. These altered cells divide and grow in the presence of signals that usually inhibit growth of cell. Cervical cancer (CC) occurs in the cervix which is also called the uterine cervix. The cervix has two different parts first is called endocervix and is covered with glandular cells. Second is called exocervix or ectocervix which is covered by squamous cells. In other words, cervical cancer frequently originates in the transformation zone of the cervix, and spreads to regional lymph nodes. Some of the risk factors which are responsible for CC development like sexual intercourse with a polygamist, first gestation at age 20 years old and below, first childbirth age at 20 years old and below, smoking, & HPV 16, 18 infections. High-risk HPVs are the causative agents of cervical cancer and, worldwide, it is estimated that about 572,624 cases of cervical cancer occur each year, which results in over 265,672 deaths. This review summarized the molecular biology of HPV and CC and its management.

Keywords: Cervical Cancer, Cervix, Endocervix, Exocervix, Human Papillomavirus

Citation: Pushpendra Pratap, Tasleem Raza, Ghazala Zaidi, Mark Rector Charles, Shipra Kunwar. Molecular Biology of Human Papillomavirus, Cervical Carcinoma and its Management. Canadian Journal of Clinical Nutrition. 2021; 9 (1): 71-88.

DOI: https://dx.doi.org/10.14206/canad.j.clin.nutr.2021.01.07     

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