MicroRNA-145 in Oral Cancer: A Short Review

Alok Singh1, Pooja Singh1*, Priyanka Singh1, Siddhartha Chandel2, Rajveer S. Chauhan3
1Department of Pathology, 2Department of Dentistry, ERA’S Lucknow Medical College and Hospital Lucknow, U.P., India. 3Editorial Board Member of Journal of Experimental Biology and Agricultural Sciences.
*Correspondence: Pooja Singh (Ph.D. Scholar). Email:poojaa.singh1989@gmail.com

ABSTRACT
Oral squamous cell carcinoma (OSCCs) is increasing very fast rate in the developed and developing countries. Nowadays in OSCCs, many  miRNAs (miRs) are playing important roles as diagnostic as well as prognostic and therapeutic biomarkers, in which miRNA-145 is one of them. MiR-145 behaves as a tumor suppressor miRNA in OSCCs, and it’s over expression promotes various cellular processes such as cell proliferation inhibition, G1 cell cycle arrest and apoptosis. miR-145 participates in different types of cancers like  pancreas, liver, prostate and breast cancer including oral cancer. This novel biomarker may be used as diagnostic as well as prognostic biomarker in different types of cancers including oral cancer also. Few more validated results are required to prove miR-145 as a diagnostic, prognostic and therapeutic biomarker in cancers. This review aims to recap about the role of miR-145 in oral cancer and its use as a diagnostic as well as prognostic biomarker.

Keywords: MicroRNA, Micro RNA-145, Oral Squamous Cell Carcinoma, Tumor Suppressor

Citation: Singh A, Singh P, Singh Pr, Chandel S, Chauhan RS. MicroRNA-145 in Oral Cancer: A Short Review. Canad J Clin Nutr 2017; 5 (1): 95-104.

DOI: http://dx.doi.org/10.14206/canad.j.clin.nutr.2017.01.09

Download