Impact of Dietary Factors on MicroRNAs Expression and Cancer Prevention

Pooja Singh1*, Alok Singh1, Rajveer S. Chauhan2, Siddhartha Chandel3
1Department of Pathology, ERA’S Lucknow Medical College and Hospital Lucknow, U.P., India. 2Editorial Board Member of Journal of Experimental Biology and Agricultural Sciences.3Department of Dentistry, ERA’S Lucknow Medical College and Hospital Lucknow, U.P., India
*Corresponding Author: Pooja Singh (PhD Scholar). E-mail:poojaa.singh1989@gmail.com

ABSTRACT
There are many epigenetic mechanisms that affect human health encompassing of microRNAs (miRs), which represents a growing class of interest, evolutionary conserved non coding RNAs, regulate gene expression at post-transcriptional level. They have been known to regulate many cellular processes, such as cellular differentiation, proliferation and apoptosis. Recent evidences suggest about the protection effect of several nutrient diet factors in cancer and several human diseases through the modulation in the expression profile of miRs. Additionally dietary factors have been considered not only as the modulator of miRs expression but also modify the target of miRs in various cancer processes such as differentiation, cell cycle progression, inflammation, angiogenesis, metastasis and apoptosis. Herein, we summarized a brief review about the impact of dietary factors on the functional aspects and expression profile of miRs, may help to provide preventive mechanisms in reduction of overburden of human diseases including cancers.

Keywords: : Nutrition, Chemoprevention, Phytochemicals, miRNA

Citation: Singh P, Singh A, Chauhan RS, Chandel S. Impact of Dietary Factors on MicroRNAs Expression and Cancer Prevention. Canad J ClinNutr 2017; 5 (2): 61-81.

DOI:http://dx.doi.org/10.14206/canad.j.clin.nutr.2017.02.06

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