Balqis Abdullah Said Al-Jahdhami, Ahmed Al-Alwai*, Mostafa I. Waly
Food Science and Nutrition Department, CAMS, Sultan Qaboos University, Oman
*Correspondence Email Address: [email protected]
ABSTRACT
Background: Brown seaweeds are abundant in Oman. They are a valuable source for many food formulations and nutraceutical products. Furthermore, protein can be extracted as a byproduct with an added value. The present research was conducted to identify the antioxidant properties of protein extracted from brown seaweed Sargassum ilicifolium (S. ilicifolium) in a rat model of cisplatin-induced nephrotoxicity. Methods: For investigation of the antioxidant effect of the extracted protein, Sprague Dawely male rats (n=40) were divided into four groups: first group: non-renal oxidative stress control (n=10), second group: renal oxidative stress control (n=10), third group: S. ilicifolium protein extract solution (n=10), and fourth group: S. ilicifolium protein extract solution with cisplatin (n=10). Results: The nephrotoxicity was induced by a single intraperitoneal injection of cisplatin (50 mg/kg body weight). Animals were given S. ilicifolium protein solution by oral gavage at 1 ml/day for a period of 4 weeks. The results showed that the renal oxidative stress control (cisplatin injected) group exhibited significant (P < 0.05) elevation in the serum creatinine and blood urea nitrogen (BUN) accompanied by total antioxidant impairment (TAC) and increasing oxidized Glutathione (GSSG) when compared to the non-renal oxidative stress control group. Conclusion: Treatment with S. ilicifolium protein showed a significant (P < 0.05) positive effect against the oxidative stress associated with cisplatin injection on the TAC, GSSG, BUN, serum creatinine, and histopathology of kidney of renal oxidative stress rat and therefore, indicated a nephron protective effect of S. ilicifolium protein and its ability to use casein as an alternative in food products.
Keywords: Antioxidant, Brown Seaweed, Cisplatin, Nephrotoxicity
Citation: Balqis Abdullah Said Al-Jahdhami, Ahmed Al-Alwai, Mostafa I. Waly. Antioxidant Properties of Protein Extracted from the Brown Seaweed (Sargassum ilicifolium) against Cisplatin-induced Nephrotoxicity in Rats. Canadian Journal of Clinical Nutrition. 2022; 10 (2): 24-36.
DOI: https://dx.doi.org/10.14206/canad.j.clin.nutr.2022.02.03
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